Incidence and Prevalence

Incidence and prevalence are terms commonly used in describing disease epidemiology.

Incidence

Incidence is the rate of new (or newly diagnosed) cases of the disease. It is generally reported as the number of new cases occurring within a period of time (e.g., per month, per year). It is more meaningful when the incidence rate is reported as a fraction of the population at risk of developing the disease (e.g., per 100,000 or per million population). Obviously, the accuracy of incidence data depends upon the accuracy of diagnosis and reporting of the disease. In some cases (including ESRD) it may be more appropriate to report the rate of treatment of new cases since these are known, whereas the actual incidence of untreated cases is not.

Incidence rates can be further categorized according to different subsets of the population – e.g., by gender, by racial origin, by age group or by diagnostic category.

Prevalence

Prevalence is the actual number of cases alive, with the disease either during a period of time (period prevalence) or at a particular date in time (point prevalence). Period prevalence provides the better measure of the disease load since it includes all new cases and all deaths between two dates, whereas point prevalence only counts those alive on a particular date.

Prevalence is also most meaningfully reported as the number of cases as a fraction of the total population at risk and can be further categorized according to different subsets of the population.

Incidence to Prevalence

The relationship between incidence and prevalence depends greatly on the natural history of the disease state being reported. In the case of an influenza epidemic, the incidence may be high but not contribute to much growth of prevalence because of the high, spontaneous rate of disease resolution. In the case of a disease that has a low (or zero) cure rate, but where maintenance treatment permits sustained survival, then incidence contributes to continuous growth of prevalence. In such cases, the limitation on prevalence growth is the mortality which occurs in the population. Obviously, prevalence will continue to grow until mortality equals or exceeds the incidence rate.

An example of this relationship is shown below.  The disease incidence is 100 per year. Mortality rate is 20% per year. As seen, prevalence grows until the death rate equals the incidence.

Another feature of the prevalence growth that should be noted is that during the earlier years the growth of prevalence is very fast, but slows towards zero growth after 15 years.

Resources:

Waning B, Montagne M. Chapter 2. Medical Surveillance and Outbreaks of Disease. In: Waning B, Montagne M, eds. Pharmacoepidemiology: Principles and Practice. New York: McGraw-Hill; 2001.

Greenberg RS, Daniels SR, Flanders WD, Eley JW, Boring JR. Chapter 2. Epidemiologic Measures. In: Greenberg RS, Daniels SR, Flanders WD, Eley JW, Boring JR, eds. Medical Epidemiology. 4th ed. New York: McGraw-Hill; 2005.

Walters RW, Kier KL. Chapter 8. The Application of Statistical Analysis in the Biomedical Sciences. In: Kier KL, Malone PM, Stanovich JE, eds. Drug Information: A Guide for Pharmacists. 4th ed. New York: McGraw-Hill; 2012.

 

P/N 101854-01 Rev A 08/2012